By Robert Lev
Adenomatous Polyps of the Colon: Pathobiological and Clinical Features consolidates the massive physique of easy technology and scientific info linked to adenomatous polyps of the colon, a lot of it encouraged via the conclusion that the majority colorectal carcinomas appear to come up in such polyps. This ebook strives to judge those info, with specific emphasis on their implications for administration of polyp-bearing matters. subject matters comprehensively explored comprise anatomy and histology of the conventional colon; pathologic features of adenomatous polyps, differential prognosis, and grading schemes for measure of dysplasia and villosity; adenomatous polyposes; histologic and epidemiologic facts for the malignant capability of adenomatous polyps; and detection and administration, with designated recognition to endoscopy, endoscopic polypectomy, the malignant polyp, and post-polypectomy surveillance schedules.
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Additional resources for Adenomatous Polyps of the Colon: Pathobiological and Clinical Features
Eosinophilic crypts have been noted in the absence of adenomatous glands, however (Lev & Grover, 1981). The possible role of the lymphoid follicles, which may be found beneath adenomatous epithelium, in the genesis of APs in humans and experimental animals has been discussed by Oohara et ai. , 1983). Oohara's illustrations of glands adjacent to such follicles are not convincingly adenomatous, however, and it is known that basophilic epithelium of nonadenomatous type may be found in that location (see Chapter 1).
However, Sugihara and Jass (1987) found no difference in UEA binding by left colon in FPC and controls. , 1980). , 1987); since DBA binds to Nacetylgalactosamine, the determinant for blood group A, this appears to contradict the above findings, but it must be remembered that N-acetylgalactosamine is undoubtedly found as a terminal residue on oligosaccharide side chains other than those in blood group A. , 1986). , 1981; 30 2. , 1988). A progressive increase in CEA staining was seen in the same villous adenoma biopsied repeatedly over a six-year period prior to its transformation into invasive carcinoma (Whitehead & Skinner, 1983).
O'Brien MJ, Zamcheck N, Burke B, Kirkham SE, Saravis CA, Gottlieb LS (1981) Immunocytochemical localization of carcinoembryonic antigen in benign and malignant colorectal tissues. Am J Clin Pathol 75:283-290.