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By John R. Baker, Ralph Muller, David Rollinson

The Advances in Parasitology sequence comprises in-depth stories on present subject matters of curiosity in modern parasitology. It contains scientific reports on parasites of significant impression, akin to trypanosomiasis and scabies, and extra conventional parts, equivalent to zoology, taxonomy, and existence historical past, which form present pondering and functions. * sequence has the second one optimum ISI influence think about the parasitology staff! (4.818 in 2002) * members are foreign specialists within the box

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Liver-associated parasites (Murray and Nathan, 1999). In another study carried out with L. major-infected mice, it was reported that whereas NOS2 plays a major role in the control of parasite number in the skin lesions and draining lymph nodes during the acute phase of the disease, both NOS2 and phox are required in these sites during the chronic phase of the infection to maintain the parasite population at a low level. , 2003) (Figure 6). Most of the studies reported above have been carried out with L.

Consequences for the respective capacity of these cells to present Leishmania Ags. 6. 1. Ability of Leishmania spp. to Induce DC Maturation and Migration It has been demonstrated in the pioneering work of Moll and collaborators that, after inoculation of mice with a large number of L. -C. ANTOINE ET AL. , 1997; Moll, 2000). It is suspected that at least some of these migrating DCs undergo maturation that makes them capable of activating naive Leishmania-specific CD4 and CD8 T lymphocytes. Several in vitro studies have been devoted to the ability of various Leishmania species to induce DC maturation but, once again, apparently conflicting results have been obtained from different laboratories.

N, DC nucleus. Bar, 5 mm. ) consequences for the respective capacity of these cells to present Leishmania Ags. 6. 1. Ability of Leishmania spp. to Induce DC Maturation and Migration It has been demonstrated in the pioneering work of Moll and collaborators that, after inoculation of mice with a large number of L. -C. ANTOINE ET AL. , 1997; Moll, 2000). It is suspected that at least some of these migrating DCs undergo maturation that makes them capable of activating naive Leishmania-specific CD4 and CD8 T lymphocytes.

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