By Waldemar Priebe
content material: Unresolved structure-activity relationships in anthracycline analogue improvement / Edward M. Acton --
Non-cross-resistant anthracyclines with decreased basicity and elevated balance of the glycosidic bond / Waldemar Priebe, Piotr Skibicki, Oscar Varela, Nouri Neamati, Marcos Sznaidman, Krzysztof Dziewiszek, Grzegorz Grynkiewicz, Derek Horton, Yiyu Zou, Yi-He Ling, and Roman Perez-Soler --
Fluorinated anthracyclinones and their glycosylated items / Antonio Guidi, Franca Canfarini, Alessandro Giolitti, Franco Pasqui, Vittorio Pestellini, and Federico Arcamone --
Semisynthetic rhodomycins and anthracycline prodrugs / Cenek Kolar, Klaus Bosslet, Jörg Czech, Manfred Gerken, Peter Hermentin, Dieter Hoffmann, and Hans-Harold Sedlacek --
man made ideas for reversal of anthracycline resistance and cardiotoxicity / Claude Monneret, Jean-Claude Florent, Jean-Pierre Gesson, Jean-Claude Jacquesy, François Tillequin, and Michel Koch --
Synthesis and organic actions of fluorinated daunorubicin and doxorubicin analogues / Tsutomu Tsuchiya and Yasushi Takagi --
Redox chemistry of anthracyclines and use of oxomorpholinyl radicals / Tad H. Koch and Giorgio Gaudiano --
Synthesis of anthraquinone analogues of associated anthracycline / Ping Ge and Richard A. Russell --
Synthesis and research of structure-activity relationships of latest sessions of anthracyclines / Antonino Suarato, Francesco Angelucci, Alberto Bargiotti, Michele Caruso, Daniela Faiardi, Laura Capolongo, Cristina Geroni, Marina Ripamonti, and Maria Grandi --
Molecular popularity of DNA by way of daunorubicin / Jonathan B. Chaires --
Adducts of DNA and anthracycline antibiotics : buildings, interactions, and actions / Jasmine Y.-T. Wang, Mark Chao, and Andrew H.-J. Wang --
DNA topoisomerases and their inhibition by way of anthracyclines / Yves Pommier --
Anthracycline antihelicase motion : new mechanism with implications for guanosine-cytidine intercalation specificity / Nicholas R. Bachur, Robin Johnson, Fang Yu, Robert Hickey, and Linda Malkas --
Membrane biophysical parameters influencing anthracycline motion / Ratna Mehta and Thomas G. Burke --
sign transduction structures in doxorubicin hydrochloride mechanism of motion / Paul Vichi, James music, Jean Hess, and Thomas R. Tritton --
research of multidrug transporter in residing cells : software to uptake and free up of anthracycline derivatives by way of drug-resistant K562 cells / Arlette Garnier-Suillerot, Frédéric Frézard, Marie-Nicole Borrel, Elene Pereira, Jolanta Tarasiuk, and Marina Fiallo --
function of reactive-oxygen metabolism in cardiac toxicity of anthracycline antibiotics / James H. Doroshow --
Amelioration of anthracycline-induced cardiotoxicity via natural chemical substances / Donald T. Witiak and Eugene H. Herman --
Use of drug vendors to ameliorate the healing index of anthracycline antibiotics / Roman Perez-Soler, Steven Sugarman, Yiyu Zou, and Waldemar Priebe.
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Additional info for Anthracycline Antibiotics. New Analogues, Methods of Delivery, and Mechanisms of Action
Again, the 2'-chlorodaunorubicin (48) in L-manno configuration showed good antitumor activity in vivo against P388 leukemia (T/C 248 at 25 mg/kg), whereas both L-gluco (50) and L-galacto (43) 2'-chloro analogues showed no activity against P388 leukemia at doses up to 50 mg/kg. 2'-Iodo-3'-deamino Daunorubicins Modified at C-5'. Very promising results of biological evaluation of 2'-halo-3'-oxy-daunorubicins and a unique observed SAR prompted synthesis of analogues modified at C-5'. AcO I 52 - R = Η (a-L-lyxo) 54 - R = CH OAc (a-L-manno) 2 AcO—Ο 53 - R = Η (β-L-Jcy/o) 55 - R = CH OAc (^-L-gluco) 2 Two modifications were considered: (a) a 6'-methyl group replaced with hydrogen and (b) a 6'-methyl group replaced with hydroxymethyl (CH2OH).
27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. ET AL. ; Neamati, N . ; Perez-Soler, R. J. Antibiot. 1990, 43, 838. ; Priebe, W. Cancer Chemother. Pharmacol. 1992, 30, 267. ; Pommier, Y. Int. J. Cancer, 1994, 58, 85-94. Chaires, J. ; Graves, D. ; Burke, T. G. J. Am. Chem. Soc. 1993, 115, 5360. Friedman, R. A. ; Manning, G. Biopolymers 1984, 23, 2671. ; Wright, H . ; Sweatman, T. ; Israel, M . Oncol. Res. 1992, 4, 343. ; Sweatman, T. ; Docter, M . ; Israel, M .
Cancer Res. 1992, 52, 3409. ; Burke, T. ; Priebe, W. Proc. Am. Chem. Soc. , CARB-30, Denver, 1993. ; Sweatman, T. ; Dockter, M . ; Priebe, W. Oncol. Res. 1993, 5, 229. , In Anthracycline Antibiotics; El Khadem, H . : New York, 1982, p. 197. ; Zamojski, A. Tetrahedron 1980, 36, 287. ; Neamati, N . ; Perez-Soler, R. Tetrahedron Lett. 1991, 32, 3313. ; Priebe, W. Proc. Am. Chem. Soc. , CARB-22, San Francisco, 1980. ; Priebe, W. Proc. Am. Chem. Soc. , CARB-11, New York, 1981. ; Varela, O. Abstr. Pap.